BDBM50590061 CHEMBL5196432

SMILES [H][C@]12CN(CC(F)(F)F)CCN1c1cc3c(N[C@H](C)c4cccc(C(F)F)c4F)nc(C)nc3cc1OCC2

InChI Key InChIKey=LLWSSGBFYYSLTH-ZBFHGGJFSA-N

Data  10 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50590061   

TargetCytochrome P450 2C8(Homo sapiens (Human))
Wuhan University Of Science And Technology

Curated by ChEMBL
LigandPNGBDBM50590061(CHEMBL5196432)
Affinity DataIC50:  3.91E+4nMAssay Description:Time-dependent inhibition of CYP2C8 (unknown origin) at 2 ul pre-incubated for 30 mins in presence or absence of NADPH incubated for 10 mins by LC/MS...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetCytochrome P450 2C8(Homo sapiens (Human))
Wuhan University Of Science And Technology

Curated by ChEMBL
LigandPNGBDBM50590061(CHEMBL5196432)
Affinity DataIC50:  4.52E+4nMAssay Description:Inhibition of CYP2C8 in human liver microsomes at 10 uM using amodiaquine as substrate preincubated for 10 mins followed by NADPH addition by LC/MS a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed